Tissue expression, serum and salivary levels of VEGF in patients with head and neck squamous cell carcinoma
Shiraz University of Medical Sciences School of Dentistry, Iran
Dr. Marziyeh Hamzavi has completed his DDS at the age of 23 years from Zahedan State University and Postdoctoral studies from Shiraz University of Medical Sciences, School of Dentistry. She has published more than 15 papers and posters in reputed journals and conferences.
Vascular endothelial growth factor (VEGF) is thought to be an important angiogenic factor that involved in tumor growth, progression and metastasis. Objective: The present study evaluate the relation between tissue expression, serum and salivary levels of VEGF in head and neck squamous cell carcinomas (HNSCCs) and their correlation with clinicopathologic features. Method and Materials: Samples were collected from 30 patients with HNSCCs and 24 healthy volunteers. Immunohistochemical analysis was used for tissue expression and ELISA was employed to measure serum and salivary levels. Results: No VEGF staining was observed in normal tissues; whereas VEGF expression was seen in six patients (20%). Mean serum level of VEGF was 83.7 ± 104.47 in patients and 50.04 ± 32.94 in controls. Mean salivary level of VEGF was 174.41 ± 115.07 in patients and 149.58 ± 101.88 in controls. No significant difference was found by Mann-Whitney statistical test between controls and patients (respectively P: 0.411, P: 0.944). No correlation was found between VEGF tissue expression and its serum and salivary level.
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